Cover: School of spadefish (Chaetodipterus faber) swimming above the oxycline at an offshore oil platform; (B) fish trapped and killed by hypoxia on Grand Isle barrier beach; (C) brown or white shrimp (Penaeus sp.) escaping hypoxia by moving to the top of a particle trap at 14 m; (D) dead portunid crab (probably Portunus gibbesii); (E) dead majid crab (Libinia dubia); (F) olive shell (Oliva sayana) displaying stress by plowing through surface sediments. See Rabalais et al. (p. 320-329). This paper is part of the symposium series in this issue that starts on p. 275. Photos by (A) Nancy Rabalais, (B) Kerry St. Pé, (C, D, E) Franklin Viola (copyrighted, used with permission), (F) Don Harper.