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The Transfer of the Coccidiostat Clopidol to Lambs by Feeding Chicken Waste¹

ABSTRACT

Broiler chickens of both sexes were fed a diet with and without 125 µg/g of the coccidiostat clopidol (3,5-dichloro-2,6-dimethyl-4-pyridinol). The waste from these animals was fermentated with a wood base and fed to lambs for a 5-mo period. The clopidol in the lamb feed, the edible tissues, and faeces was measured at slaughter by gas chromatography (GC) with electron capture (EC) detection and confirmed by mass spectrometry (MS). Lamb silage from chicken waste contained 70 to 80 µg/g clopidol. Kidney levels of treated groups averaged between 0.4 to 0.75 µg/g, while those in liver were 0.2 to 0.4 µg/g. Muscle and fat tissue contained 0.1 µg/g and lower concentrations. Corresponding values for blood and faeces were 0.1 to 0.5 and 0.2 to 0.8 µg/g. An additional 10 to 30% more clopidol was present in the kidney, liver, and blood but not the faeces in the form of the glucuronide conjugate. Clopidol was passed on from the chickens to the lambs by feeding of chicken waste but did not appear to accumulate in the lambs.

Key Words: conjugates • tissue residues

¹ Contribution from the laboratories of the Health Protection Branch, the Nova Scotia Agricultural College, and the Nova Scotia Dep. of Agriculture operated by the Federal Government of Canada and Provincial Government of Nova Scotia.

² Research Scientist, Technician, and Research Scientist, respectively, Food Div., Health Protection Branch, Ottawa, Ontario, K1A OL2, Canada; Associate Professor, Dep. of Animal Science, Nova Scotia Agricultural College, Truro, Nova Scotia, B2N 5E3, Canada; and Poultry Specialist, Livestock Services, Nova Scotia Dep. of Agriculture, Truro, Nova Scotia, Canada, respectively.

Received for publication September 6, 1978.